What is secondary breast cancer in the brain? Newly diagnosed or worried about a symptom? What is leptomeningeal metastases?
NCBI Bookshelf. DuenasRahul Jandialand George Somlo. Duenas1 Rahul Jandial1 and George Somlo 2.
Metastasizing breast cancers typically seek out the bones, lung, and brain. Brain metastases are especially dangerous; many women survive for less than a year after diagnosis. How is the cancer able to get past the blood brain barrier?
Because of improvements in the treatment of patients with metastatic breast cancer, the development of brain metastases BM has become a major limitation of life expectancy and quality of life for many breast cancer patients. The improvement of management strategies for BM is thus an important clinical challenge, especially among high-risk patients such as human epidermal growth factor receptor 2-positive and triple-negative patients. However, the formation of BM as a multistep process is thus far poorly understood.
Secondary breast cancer is breast cancer that has spread from the breast to other parts of the body. Breast cancer starts as a lump in the breast - this is primary breast cancer. In many women, primary breast cancer does not come back after treatment.
Correspondence Address: Dr. E-mail: nounou usj. Brain metastasis is a major cause of death in patients with solid cancers.
Brain metastases are the most common central nervous system tumors in adults, and incidence of brain metastases is increasing due to both improved diagnostic techniques e. Outcomes of patients remain disappointing and treatment options are limited, usually involving multimodality approaches. Brain metastases represent an unmet medical need in solid tumor care, especially in breast cancer, where brain metastases are frequent and result in impaired quality of life and death.
Skip to Content. Use the menu to see other pages. This section explains the types of treatments that are the standard of care for metastatic breast cancer.
Ninety percent of cancer deaths are from cancer spread. Breast cancer patients, for example, typically do not die because cancer returns in their breast, they die because it spreads to other parts of their body. The most dangerous of which is the brain. Approximately 40 percent of all women with HER2-positive breast cancer will develop brain metastases.